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Systematic reviews: Protocols


PROSPERO is an international database of prospectively registered systematic reviews in health and social care. Key features from the review protocol are recorded and maintained as a permanent record. Systematic reviews should be registered at inception (i.e. at the protocol stage) to help avoid unplanned duplication and to enable comparison of reported review methods with what was planned in the protocol.

To register your review of learn more about PROSPERO, click here.

Other Protocols

Typical clinical protocol

International registration platform:

European registration platform:

Plus mange flere:

Not typical clinical protocols

Registered reports

Systematic review protocol

A systematic review protocol describes the rationale, hypothesis, and planned methods of the review. It should be prepared before a review is started and used as a guide to carry out the review. Detailed protocols should be developed a priori, made publicly available, and registered in a registry such as PROSPERO. The protocol also includes  a detailed plan for how and where the literature will be searched, data extracted and synthesized.

Cochrane protocol

Proposing and registering new Cochrane Reviews

All Cochrane systematic reviews are first registered as titles with a Cochrane Review Group (CRG). Registering your title is important to prevent duplication of effort with other authors, and to make sure your topic is appropriate for a Cochrane review. There are 52 CRGs that each focus on a particular area of health. CRGs are coordinated by an editorial team who edit and publish completed reviews in the Cochrane Library. Unlike other journals, your CRG will provide support and advice throughout the review process.

  1. The author team chooses an available topic and registers a title with the appropriate CRG.
  2. Authors prepare a protocol and submit it to the CRG for peer review and publication.
  3. When the protocol has been approved, authors begin searching for studies and analysing their results.
  4. Authors prepare the final review report and submit it for peer review and publication.
  5. After the review is published, the authors continue to update it periodically.

Equator Network

Equator network 
(Enhancing the QUAlity and Transparency Of health Research) is an international initiative that seeks to improve the reliability and value of published health research literature by promoting transparent and accurate reporting and wider use of robust reporting guidelines.


PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols)
Tjekliste til at udvikle og afrapportere protokollen.

PRISMA Flow chart

Campbell Collaboration

An international social science research network.

Cambell Systematic Reviews Journal